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Invitrogen
hnRNP AB Polyclonal Antibody
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FIGURE: 1 / 6
hnRNP AB Antibody (PA5-27549) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of hnRNP AB was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: hnRNP AB Polyclonal Antibody (Product # PA5 27549) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
PA5-27549
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Zebrafish
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human hnRNP AB. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Amount
26 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431.
Predicted reactivity: Mouse (97%), Rat (97%), Pig (100%), Chicken (92%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABBP-1; apobec-1 binding protein 1; APOBEC1-binding protein 1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1; Heterogeneous nuclear ribonucleoprotein A/B; hnRNP A/B; hnRNP type A/B protein; unnamed protein product
Gene Aliases: ABBP1; HNRNPAB; HNRPAB
UniProt ID: (Human) Q99729
Entrez Gene ID: (Human) 3182
epithelial to mesenchymal transition
regulation of gene expression
positive regulation of macromolecule biosynthetic process
mRNA modification
positive regulation of transcription, DNA-templated
negative regulation of RNA metabolic process
regulation of cellular localization
cellular response to amino acid stimulus
chromosomal 5-methylcytosine DNA demethylation pathway
regulation of intracellular mRNA localization
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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