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Invitrogen
TBX15/TBX18 Polyclonal Antibody
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Product Details
PA5-36143
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 131-180 of human TBX15
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 64 kDa.
Purity is >95% by SDS-PAGE.
Target Information
T-box transcription factors are a group of phylogenetically conserved genes that contain a uniquely defining DNA-binding domain, the T-box domain. These genes are believed to be involved in the regulation of development processes. In mouse embryo development, Tbx15 is expressed at the beginning of day 9.5, primarily in the craniofacial region and in the developing limbs. Twelve human T-box genes have been isolated so far. TBX 18 has been reported to be involved in numerous development processes and to act as an antiapoptotic factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: droopy ear; MmTBx8; T-box 14; T-box 15; T-box 18; T-box protein 14; T-box protein 15; T-box protein 18; T-box transcription factor TBX14; T-box transcription factor TBX15; T-box transcription factor TBX18; unnamed protein product
Gene Aliases: 2810012F10Rik; 2810404D13Rik; CAKUT2; de; PUJO; TBX14; TBX15; TBX18; Tbx8
UniProt ID: (Human) Q96SF7, (Human) O95935, (Mouse) O70306, (Mouse) Q9EPZ6
Entrez Gene ID: (Human) 6913, (Human) 9096, (Mouse) 21384, (Rat) 295315, (Rat) 315870, (Mouse) 76365
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription corepressor activity
protein heterodimerization activity
RNA polymerase II transcription factor binding
molecular_function
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
somitogenesis
sinoatrial node development
morphogenesis of embryonic epithelium
neural plate anterior/posterior regionalization
smooth muscle cell differentiation
sinoatrial node cell fate commitment
sinoatrial node cell development
ureter development
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
regulation of SA node cell action potential
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
sensory perception of sound
biological_process
anterior/posterior axis specification
positive regulation of cell-cell adhesion
cell differentiation
anatomical structure formation involved in morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
positive regulation of mesenchymal cell proliferation involved in ureter development
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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