Immunogen sequence: GQQPPMGMMG QVNQGNHMMG QRQIPPYRP
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
The transcriptional coactivator SYT (synovial translocation protein) contains a conserved amino terminal SNH domain and a carboxy terminal QPGY domain, which is a functioning transcriptional activating sequence. Synovial sarcoma translocation (SSX) proteins, including SSX1-5, are transcriptional repressors that contain a repressor domain in their carboxy termini. SSX proteins are localized to the nucleus and expressed in testis and several types of cancers and, therefore, they are classified as C/T (cancer/testis) antigens. The t(x;18) translocation results in the fusion of the amino terminus of SYT to the carboxy terminus of either SSX1 or SSX2; both fusions result in the production of transcriptional activators.
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Protein Aliases: Protein SSXT; Protein SYT; SS18; SSXT; Synovial sarcoma translocated to X chromosome protein; synovial sarcoma translocation, chromosome 18; synovial sarcoma, translocated to X chromosome; SYT
Gene Aliases: SS18; SSXT; SYT
UniProt ID: (Human) Q15532
Entrez Gene ID: (Human) 6760