Immunogen sequence: KAFGPPHEGPL QGLVASRIET YGGRHRASAQ STTGRLYPRG YPVLDPSRRR LQQYVPFARG SGQARGLSPM RLRDPEPEKR\r
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 73%.
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Protein Aliases: MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; Myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6
Gene Aliases: MyoGEF; PLEKHG6
UniProt ID: (Human) Q3KR16
Entrez Gene ID: (Human) 55200