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Immunogen sequence: PKLSTSGIPE KFHGTDFDTV FWKCDMQKLT VDELKRLLYD TFCEHLSMKD IENIIMTEEE SHLGTAEECP VDVETCSNQQ I; Positive Samples: Mouse brain, Mouse lung, Mouse kidney, Rat lung, Rat kidney; Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Single-pass type IV membrane protein, perinuclear region, trans-Golgi network membrane
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
โ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CaBP7; Calcium-binding protein 7; calcium-binding protein CaBP7; calneuron 2; Calneuron II; Calneuron-2; calneuron-II
Gene Aliases: CABP7; CALN2; rCaBP7
UniProt ID: (Human) Q86V35, (Mouse) Q91ZM8, (Rat) Q66H96
Entrez Gene ID: (Human) 164633, (Mouse) 192650, (Rat) 360970
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