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Proteintech
PABPC1/PABP Polyclonal Antibody
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Product Details
10970-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PABPC1,PABP Fusion Protein Ag1422 (287-636 aa encoded by BC015958)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RITRYQGVN LYVKNLDDGI DDERLRKEFS PFGTITSAKV MMEGGRSKGF GFVCFSSPEE ATKAVTEMNG RIVATKPLYV ALAQRKEERQ AHLTNQYMQR MASVRAVPNP VINPYQPAPP SGYFMAAIPQ TQNRAAYYPP SQIAQLRPSP RWTAQGARPH PFQNMPGAIR PAAPRPPFST MRPASSQVPR VMSTQRVANT STQTMGPRPA AAAAAATPAV RTVPQYKYAA GVRNPQQHLN AQPQVTMQQP AVHVQGQEPL TASMLASAPP QEQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLH MLESPESLRS KVDEAVAVLQ AHQAKEAAQK AVNSATGVPT V (287-636 aa encoded by BC015958)
Target Information
The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4), and PABP3 (PABPC3). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PABP 1; PABP-1; poly A binding protein 1; poly(A) binding protein, cytoplasmic 2; poly(A)-binding protein 1; Polyadenylate-binding protein 1; unnamed protein product
Gene Aliases: ePAB; PAB1; PABP; PABP1; PABPC1; PABPC2; PabpI; PABPL1
UniProt ID: (Human) P11940, (Rat) Q9EPH8, (Mouse) P29341
Entrez Gene ID: (Human) 26986, (Rat) 171350, (Mouse) 18458
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA processing
RNA splicing
gene silencing by RNA
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA splicing, via spliceosome
positive regulation of viral genome replication
mRNA stabilization
CRD-mediated mRNA stabilization
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of cytoplasmic translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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