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Proteintech
PABPC4 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-14960
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PABPC4 fusion protein Ag6813
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: QERISRYQG VNLYIKNLDD TIDDEKLRKE FSPFGSITSA KVMLEDGRSK GFGFVCFSSP EEATKAVTEM NGRIVGSKPL YVALAQRKEE RKAHLTNQYM QRVAGMRALP ANAILNQFQP AAGGYFVPAV PQAQGRPPYY TPNQLAQMRP NPRWQQGGRP QGFQGMPSAI RQSGPRPTLR HLAPTGNAPA SRGLPTTTQR VGVPTAVQNL APRAAVAAAA PRAVAPYKYA SSVRSPHPAI QPLQAPQPAV HVQGQEPLTA SMLAAAPPQE QKQMLGERLF PLIQTMHSNL AGKITGMLLE IDNSELLHML ESPESLRSKV DEAVAVLQAH HAKKEAAQKV GAVAAATS
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activated-platelet protein 1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP-4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; Polyadenylate-binding protein 4
Gene Aliases: APP-1; APP1; iPABP; PABP4; PABPC4
UniProt ID: (Human) Q13310
Entrez Gene ID: (Human) 8761, (Rat) 298510, (Mouse) 230721
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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