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PACAP-38 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BS-0200R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PACAP-38, amino acids 31-38.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenylate cyclase activating polypeptide 1 (pituitary); pituitary adenylate cyclase activating polypeptide 1; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); prepro-PACAP; unnamed protein product
Gene Aliases: PACAP
UniProt ID: (Human) P18509, (Mouse) O70176, (Rat) P13589
Entrez Gene ID: (Human) 116, (Mouse) 11516, (Rat) 24166
receptor binding
hormone activity
neuropeptide hormone activity
protein binding
pituitary adenylate cyclase activating polypeptide activity
type 1 vasoactive intestinal polypeptide receptor binding
type 2 vasoactive intestinal polypeptide receptor binding
peptide hormone receptor binding
pituitary adenylate cyclase-activating polypeptide receptor binding
ovarian follicle development
behavioral fear response
histamine secretion
negative regulation of acute inflammatory response to antigenic stimulus
negative regulation of acute inflammatory response to non-antigenic stimulus
cAMP biosynthetic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
positive regulation of neuron projection development
insulin secretion
neuron projection development
positive regulation of interleukin-6 production
regulation of protein localization
negative regulation of GTPase activity
vasodilation
negative regulation of potassium ion transport
positive regulation of GTPase activity
negative regulation of cell cycle
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
positive regulation of growth hormone secretion
negative regulation of glial cell proliferation
positive regulation of ERK1 and ERK2 cascade
regulation of oligodendrocyte progenitor proliferation
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of somatostatin secretion
positive regulation of cold-induced thermogenesis
positive regulation of cAMP/PKA signal transduction
pituitary gland development
response to starvation
response to ethanol
cellular response to glucocorticoid stimulus
cell-cell signaling
female pregnancy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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