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Proteintech
PADI4 Polyclonal Antibody
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Product Details
17373-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PADI4 Fusion Protein Ag11068 (317-663 aa encoded by BC025718)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EDFLKSVTT LAMKAKCKLT ICPEEENMDD QWMQDEMEIG YIQAPHKTLP VVFDSPRNRG LKEFPIKRVM GPDFGYVTRG PQTGGISGLD SFGNLEVSPP VTVRGKEYPL GRILFGDSCY PSNDSRQMHQ ALQDFLSAQQ VQAPVKLYSD WLSVGHVDEF LSFVPAPDRK GFRLLLASPR SCYKLFQEQQ NEGHGEALLF EGIKKKKQQK IKNILSNKTL REHNSFVERC IDWNRELLKR ELGLAESDII DIPQLFKLKE FSKAEAFFPN MVNMLVLGKH LGIPKPFGPV INGRCCLEEK VCSLLEPLGL QCTFINDFFT YHIRHGEVHC GTNVRRKPFS FKWWNMVP (317-663 aa encoded by BC025718)
Target Information
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HL-60 PAD; PAD type IV; PAD-R4; PADI-H protein; peptidyl arginine deiminase, type 4; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4
Gene Aliases: PAD; PAD4; PADI4; PADI5; PDI4; PDI5
UniProt ID: (Human) Q9UM07, (Rat) O88807, (Mouse) Q9Z183
Entrez Gene ID: (Human) 23569, (Rat) 29512, (Mouse) 18602
chromatin organization
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular protein modification process
chromatin modification
protein citrullination
stem cell population maintenance
histone H3-R26 citrullination
histone citrullination
innate immune response
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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