PA5-29224 targets PAK1 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29224 immunogen is recombinant fragment corresponding to a region within amino acids 167 and 436 of Human PAK1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.
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Protein Aliases: activated protein kinase alpha; Alpha-PAK; CDC42/RAC effector kinase PAK-A; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; p68-PAK; PAK-1; PAKalpha; Protein kinase MUK2; Serine/threonine-protein kinase PAK 1; STE20 homolog; STE20 homolog, yeast; yeast; yeast)
Gene Aliases: AW045634; PAK-1; PAK1; Paka; PAKalpha