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QED Bioscience
PAPK (ALS2CR2) Polyclonal Antibody
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Product Details
28107-100UG
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 399-418 (SPWSELEFQFPDDKDPVWEF) of mouse PAPK conjugated to KLH at the C-terminus.
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; ILP-interacting protein homolog; MGC102916; polyploidy associated protein kinase; Polyploidy-associated protein kinase; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
Gene Aliases: AA792893; Als2cr2; B830008M19; D1Ucla2; ILPIP; ILPIPA; Papk; PRO1038; Stradb; Syradb
UniProt ID: (Mouse) Q8K4T3
Entrez Gene ID: (Mouse) 227154
cell morphogenesis
protein phosphorylation
protein export from nucleus
cytoskeleton organization
cell cycle
JNK cascade
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
actin cytoskeleton organization
activation of protein kinase activity
regulation of MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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