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Proteintech
PARD3 Polyclonal Antibody
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Product Details
11085-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PARD3 Fusion Protein Ag1565 (217-497 aa encoded by BC011711)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
PARD3 has three splice isoforms at 100 kDa, 150 kDa, and 180 kDa. This polyclonal antibody raised against C-terminal 281 amino acids of human PARD3 recognizes these three isoforms.
Immunogen sequence: RERDYAEIQ DFHRTFGCDD ELMYGGVSSY EGSMALNARP QSPREGHMMD ALYAQVKKPR NSKPSPVDSN RSTPSNHDRI QRLRQEFQQA KQDEDVEDRR RTYSFEQPWP NARPATQSGR HSVSVEVQMQ RQRQEERESS QQAQRQYSSL PRQSRKNASS VSQDSWEQNY SPGEGFQSAK ENPRYSSYQG SRNGYLGGHG FNARVMLETQ ELLRQEQRRK EQQMKKQPPS EGPSNYDSYK KVQDPSYAPP KGPFRQDVPP SPSQVARLNR LQTPEKGRPF YS (217-497 aa encoded by BC011711)
Target Information
This gene encodes a member of the kinesin 4 or subfamily of kinesin related proteins. This subfamily is also referred to as the chromokinesins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ASBP; ASIP; atypical PKC isotype-specific interacting protein; Atypical PKC isotype-specific-interacting protein; atypical PKC-specific binding protein; Atypical PKC-specific-binding protein; bazooka; CTCL tumor antigen se2-5; Ephrin-interacting protein; FLJ21015; PAR-3; par-3 (partitioning defective 3) homolog; par-3 family cell polarity regulator alpha; par-3 partitioning defective 3 homolog; PAR3-alpha; PARD-3; Partitioning defective 3 homolog; partitioning-defective 3 homolog; PHIP; protein phosphatase 1, regulatory subunit 118; RP11-406D17.1; three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)
Gene Aliases: AA960621; AI256638; ASIP; Baz; D8Ertd580e; Par-3; PAR3; PAR3A; PAR3alpha; PARD-3; PARD3; PARD3A; Phip; PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2
UniProt ID: (Human) Q96RM6, (Mouse) Q99NH2, (Rat) Q9Z340
Entrez Gene ID: (Human) 56288, (Mouse) 93742, (Rat) 81918
microtubule cytoskeleton organization
apical constriction
protein targeting to membrane
cell cycle
establishment or maintenance of cell polarity
negative regulation of peptidyl-threonine phosphorylation
single organismal cell-cell adhesion
myelination in peripheral nervous system
cell differentiation
positive regulation of myelination
regulation of actin filament-based process
wound healing, spreading of cells
cell division
centrosome localization
regulation of cellular localization
bicellular tight junction assembly
establishment of epithelial cell polarity
protein complex assembly
transforming growth factor beta receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
axonogenesis
asymmetric cell division
establishment or maintenance of epithelial cell apical/basal polarity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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