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          • Primary Antibodies ›
          • DJ-1 Antibodies

          Invitrogen

          PARK7 Polyclonal Antibody

          View all (43) DJ-1 antibodies

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          Cite PARK7 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (4)
          PARK7 Antibody in Western Blot (WB)
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          PARK7 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          PARK7 Antibody (PA5-118141) in WB

          Western Blot using PARK7 Polyclonal Antibody (Product # PA5-118141) at 1:500 dilution. Lane A: Jurkat Whole Cell Lysate, Lane B: HeLa Whole Cell Lysate, Lane C: 293 Whole Cell Lysate, Lane D: MCF-7 Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary antibody: Goat Anti-Rabbit IgG (H+L)/HRP at 1:10,000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 20 kDa. Observed band size: 23 kDa. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          PARK7 Antibody in Western Blot (WB)
          PARK7 Antibody in Western Blot (WB)
          PARK7 Antibody in Immunoprecipitation (IP)
          PARK7 Antibody in Immunoprecipitation (IP)
          PARK7 Polyclonal Antibody

          Product Details

          PA5-118141

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          ELISA (ELISA)

          1:5,000-1:10,000
          -

          Immunoprecipitation (IP)

          1-5 µL/mg of lysate
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant Human PARK7/DJ-1 Protein (1-189).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Purification

          Antigen affinity chromatography, Protein A

          Storage buffer

          PBS

          Contains

          no preservative

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2902741

          Target Information

          The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: CTA-215D11.1; DJ-1; early onset 7; epididymis secretory sperm binding protein Li 67p; FLJ27376; FLJ34360; FLJ92274; Maillard deglycase; Oncogene DJ1; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; parkinson protein 7; Parkinsonism-associated deglycase; protein deglycase DJ-1; Protein DJ-1; Protein/nucleic acid deglycase DJ-1; unnamed protein product

          View more View less

          Gene Aliases: DJ-1; DJ1; GATD2; HEL-S-67p; PARK7

          View more View less

          UniProt ID: (Human) Q99497

          View more View less

          Entrez Gene ID: (Human) 11315

          View more View less

          Function(s)
          core promoter sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity RNA binding mRNA binding receptor binding copper ion binding protein binding enzyme activator activity peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor hydrolase activity oxygen sensor activity enzyme binding kinase binding cytokine binding peptidase inhibitor activity receptor activator activity tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity protein deglycase activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding cadherin binding mercury ion binding androgen receptor binding peroxiredoxin activity ubiquitin-protein transferase inhibitor activity scaffold protein binding DNA-binding transcription factor binding cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity
          Process(es)
          synaptic transmission, dopaminergic positive regulation of acute inflammatory response to antigenic stimulus DNA repair proteolysis autophagy inflammatory response cellular response to DNA damage stimulus response to oxidative stress mitochondrion organization Ras protein signal transduction single fertilization adult locomotory behavior methylglyoxal metabolic process detoxification of copper ion positive regulation of gene expression negative regulation of gene expression lactate biosynthetic process removal of superoxide radicals insulin secretion protein repair androgen receptor signaling pathway positive regulation of protein complex assembly negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of TRAIL production positive regulation of interleukin-8 production negative regulation of protein sumoylation cellular response to oxidative stress cellular response to reactive oxygen species cellular response to glyoxal negative regulation of protein catabolic process response to hydrogen peroxide glucose homeostasis hydrogen peroxide metabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion protein stabilization dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling membrane depolarization membrane hyperpolarization regulation of androgen receptor signaling pathway detoxification of hydrogen peroxide methylglyoxal catabolic process to lactate cellular response to hydrogen peroxide detection of oxidative stress guanine deglycation guanine deglycation, methylglyoxal removal guanine deglycation, glyoxal removal cellular detoxification of aldehyde cellular detoxification of methylglyoxal positive regulation of protein localization to nucleus regulation of synaptic vesicle endocytosis negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of fibril organization positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of dopamine biosynthetic process glyoxal metabolic process glyoxal catabolic process positive regulation of L-dopa biosynthetic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process positive regulation of mitophagy negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.

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