PA1-107 has successfully been used in Western blot for detecting overexpressed and recombinant human Pax3 protein, but may not be suitable for detecting endogenous Pax3.
By immunofluorescence, PA1-107 has been used to stain frozen embryonic mouse brain tissue.
PA1-107 has been validated for IP using overexpressed Pax3 protein.
Pax 3 (Paired Box 3) is a transcription factor that is involved in development of the peripheral nervous system, melanocytes, some vascular smooth muscle, and a number of other derivatives. It regulates neurogenesis in pre-migratory neural crest cells from the dorsal neural tube, and in myogenic progenitors in the presomitic mesoderm and the hypaxial somites. Alternative splicing results in isoforms having different C-termini.
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Protein Aliases: CDHS; HUP2; Paired Box 3; Paired Box Gene 3; Paired Box Homeotic Gene 3; Paired box protein Pax-3; Paired Box Protein-3; Paired Domain Gene 3; Paired Domain Gene HuP2; PAX3/FKHR fusion; Waardenburg Syndrome 1; WS1; WS3
Gene Aliases: CDHS; HUP2; Pax-3; PAX3; Sp; splotch; WS1; WS3