Keep as concentrated solution.
Positive Control: 293T, HeLa, mouse brain, rat brain, PAX6-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
PAX genes encode nuclear transcription factors which are regarded as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters' anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AN antibody; AN2 antibody; Aniridia type II protein; aniridia type II protein antibody; D11S812E antibody; Dickie's small eye; MGC17209 antibody; MGDA antibody; Oculorhombin; oculorhombin antibody; paired box 6 antibody; paired box gene 6; paired box homeotic gene 6; paired box homeotic gene-6; paired box homeotic gene-6 antibody; Paired box protein Pax-6; paired box protein Pax-6 antibody; PAX6 antibody; small eye; WAGR antibody
Gene Aliases: 1500038E17Rik; AEY11; AN; AN2; D11S812E; Dey; FVH1; Gsfaey11; MGDA; Pax-6; PAX6; Sey; WAGR