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Fabgennix
PBR Polyclonal Antibody
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Product Details
TSPO-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid sequence on 18 kDa mitochondrial benzodiazepine receptor protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; Mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein; translocator protein (18kDa)
Gene Aliases: BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; TSPO
UniProt ID: (Human) P30536, (Rat) P16257
Entrez Gene ID: (Human) 706, (Rat) 24230
steroid biosynthetic process
ion transport
chloride transport
lipid transport
chemical synaptic transmission
aging
glial cell migration
response to manganese ion
response to vitamin B1
positive regulation of necrotic cell death
peripheral nervous system axon regeneration
adrenal gland development
response to progesterone
negative regulation of tumor necrosis factor production
response to testosterone
response to drug
positive regulation of apoptotic process
negative regulation of nitric oxide biosynthetic process
response to pain
behavioral response to pain
response to axon injury
regulation of steroid biosynthetic process
positive regulation of mitochondrial depolarization
positive regulation of calcium ion transport
contact inhibition
positive regulation of glial cell proliferation
negative regulation of glial cell proliferation
cellular response to lipopolysaccharide
cellular response to zinc ion
cellular hypotonic response
positive regulation of reactive oxygen species metabolic process
protein targeting to mitochondrion
heme biosynthetic process
anion transport
apoptotic process
signal transduction
steroid metabolic process
cell proliferation
negative regulation of protein ubiquitination
regulation of cholesterol transport
maintenance of protein location in mitochondrion
negative regulation of mitophagy
negative regulation of ATP metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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