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OriGene

PCAF Polyclonal Antibody

View all (29) PCAF antibodies

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Product Details

TA590645

Applications
Tested Dilution
Publications

ELISA (ELISA)

1:100-1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DNA immunization. This antibody is specific for the Middle Region of the target protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0927 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CREBBP-associated factor; Histone acetylase PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Spermidine acetyltransferase KAT2B

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Gene Aliases: CAF; KAT2B; P/CAF; PCAF

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UniProt ID: (Human) Q92831

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Entrez Gene ID: (Human) 8850

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding chromatin binding transcription cofactor activity transcription coactivator activity diamine N-acetyltransferase activity histone acetyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding enzyme activator activity H3 histone acetyltransferase activity acetyltransferase activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups protein kinase binding histone acetyltransferase binding histone deacetylase binding histone acetyltransferase activity (H3-K9 specific) peptide-lysine-N-acetyltransferase activity DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter by glucose gluconeogenesis regulation of DNA repair chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein acetylation ubiquitin-dependent protein catabolic process fatty acid biosynthetic process heart development memory negative regulation of cell proliferation regulation of gene expression positive regulation of neuron projection development N-terminal peptidyl-lysine acetylation internal peptidyl-lysine acetylation cellular response to insulin stimulus cellular response to oxidative stress vasodilation regulation of RNA splicing negative regulation of fatty acid biosynthetic process positive regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process positive regulation of gene expression, epigenetic positive regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development negative regulation of centriole replication positive regulation of lipid biosynthetic process rhythmic process regulation of cell division attachment of mitotic spindle microtubules to kinetochore regulation of cell cycle limb development regulation of small molecule metabolic process cellular response to parathyroid hormone stimulus negative regulation of ferroptosis positive regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of rRNA processing
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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