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Proteintech
PCBP2 Polyclonal Antibody
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Product Details
15070-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PCBP2 Fusion Protein Ag7102 (1-362 aa encoded by BC001155)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against a full-length human PCBP2 protein.
Immunogen sequence: MDTGVIEGG LNVTLTIRLL MHGKEVGSII GKKGESVKKM REESGARINI SEGNCPERII TLAGPTNAIF KAFAMIIDKL EEDISSSMTN STAASRPPVT LRLVVPASQC GSLIGKGGCK IKEIRESTGA QVQVAGDMLP NSTERAITIA GIPQSIIECV KQICVVMLES PPKGVTIPYR PKPSSSPVIF AGGQDRYSTG SDSASFPHTT PSMCLNPDLE GPPLEAYTIQ GQYAIPQPDL TKLHQLAMQQ SHFPMTHGNT GFSGIESSSP EVKGYWAGLD ASAQTTSHEL TIPNDLIGCI IGRQGAKINE IRQMSGAQIK IANPVEGSTD RQVTITGSAA SISLAQYLIN VRLSSETGGM GSS (1-362 aa encoded by BC001155)
Target Information
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha CP2; Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2; heterogenous nuclear ribonucleoprotein E2; hnRNP E2; MGC110998; Poly(rC)-binding protein 2; rCbinding protein 2
Gene Aliases: hnRNP-E2; HNRNPE2; HNRPE2; PCBP2
UniProt ID: (Human) Q15366
Entrez Gene ID: (Human) 5094
mRNA splicing, via spliceosome
gene expression
mRNA metabolic process
negative regulation of type I interferon production
viral RNA genome replication
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of defense response to virus
defense response to virus
IRES-dependent viral translational initiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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