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Invitrogen
PCID2 Polyclonal Antibody
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FIGURE: 1 / 1
PCID2 Antibody (PA5-40118) in WB
PCID2 Polyclonal Antibody detects PCID2 protein by western blot analysis. Whole cell extracts (30 µg) was separated by 10% SDS-PAGE, and the membrane was blotted with PCID2 Polyclonal Antibody (Product # PA5-40118) diluted by 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-40118
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PCID2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% Thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HCT116 cells.
Predicted reactivity: Mouse (94%), Rat (94%), Zebrafish (83%), Xenopus laevis (91%), Chicken (94%), Chimpanzee (100%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSN12-like protein; PCI domain-containing protein 2; RP11-98F14.6; unnamed protein product
Gene Aliases: A730042J05Rik; F10; HT004; PCID2; RGD1307041
UniProt ID: (Human) Q5JVF3, (Mouse) Q8BFV2
Entrez Gene ID: (Human) 55795, (Mouse) 234069, (Rat) 361182
negative regulation of apoptotic process
regulation of mRNA stability
positive regulation of B cell differentiation
positive regulation of transcription, DNA-templated
spleen development
positive regulation of mitotic cell cycle spindle assembly checkpoint
negative regulation of cysteine-type endopeptidase activity
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
transcription elongation from RNA polymerase II promoter
protein transport
poly(A)+ mRNA export from nucleus
negative regulation of gene expression, epigenetic
mRNA transport
negative regulation of lymphoid progenitor cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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