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Invitrogen
PDCD10 Polyclonal Antibody, DyLight™ 488
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FIGURE: 1 / 1
PDCD10 Antibody (PA5-79792) in Flow
Flow Cytometry of PDCD10 in K562 cells (blue line), isotype control rabbit IgG (green line) and unlabeled (red line). Samples were blocked with 10% goat serum and then incubated with PDCD10 Polyclonal Antibody, DyLight™ 488 (Product # PA5-79792) at a dilution of 1 μg (per 1x10^6 cells) for 30 min at 20°C.
Product Details
PA5-79792
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human PDCD10 recombinant protein (Position: M1-A212).
Conjugate
Excitation/Emission Max
492/519 nm
View spectra
Form
Liquid
Concentration
200 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control - Flow: K562 cell.
Target Information
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein 15; Cerebral cavernous malformations 3 protein; MGC1212; MGC24477; PDCD 10; Programmed cell death protein 10; TF-1 cell apoptosis-related protein 15
Gene Aliases: CCM3; PDCD10; TFAR15
UniProt ID: (Human) Q9BUL8
Entrez Gene ID: (Human) 11235
angiogenesis
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
positive regulation of stress-activated MAPK cascade
positive regulation of peptidyl-serine phosphorylation
regulation of Rho protein signal transduction
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
response to hydrogen peroxide
negative regulation of apoptotic process
stress fiber assembly
positive regulation of MAP kinase activity
wound healing, spreading of cells
positive regulation of Notch signaling pathway
protein stabilization
establishment of Golgi localization
positive regulation of protein serine/threonine kinase activity
negative regulation of cell migration involved in sprouting angiogenesis
Golgi reassembly
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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