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Proteintech
PDCD2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
10725-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Zebrafish
Published species
Human,
Mouse,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDCD2 Fusion Protein Ag1139 (1-344 aa encoded by BC008378)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
10725-1-AP is a rabbit polyclonal antibody raised against full-length PDCD2 of human origin.
Immunogen sequence: MAAAGARPV ELGFAESAPA WRLRSEQFPS KVGGRPAWLG AAGLPGPQAL ACELCGRPLS FLLQVYAPLP GRPDAFHRCI FLFCCREQPC CAGLRVFRNQ LPRKNDFYSY EPPSENPPPE TGESVCLQLK SGAHLCRVCG CLGPKTCSRC HKAYYCSKEH QTLDWRLGHK QACAQPDHLD HIIPDHNFLF PEFEIVIETE DEIMPEVVEK EDYSEIIGSM GEALEEELDS MAKHESREDK IFQKFKTQIA LEPEQILRYG RGIAPIWISG ENIPQEKDIP DCPCGAKRIL EFQVMPQLLN YLKADRLGKS IDWGILAVFT CAESCSLGTG YTEEFVWKQD VTDTP (1-344 aa encoded by BC008378)
Target Information
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: programmed cell death protein 2; programmed cell death-2/Rp8 homolog; unnamed protein product; zinc finger MYND domain-containing protein 7; zinc finger protein Rp-8
Gene Aliases: Pcd2; RP-8; RP8; zgc:63685; ZMYND7
UniProt ID: (Human) Q16342, (Mouse) P46718
Entrez Gene ID: (Human) 5134, (Mouse) 18567, (Zebrafish) 393370
ribosomal small subunit biogenesis
regulation of hematopoietic progenitor cell differentiation
regulation of mitotic nuclear division
erythrocyte differentiation
hematopoietic stem cell differentiation
positive regulation of apoptotic process
positive regulation of hematopoietic stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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