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Bethyl Laboratories
PDCD2 Polyclonal Antibody
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FIGURE: 1 / 1
PDCD2 Antibody (A303-598A) in IP
Detection of human PDCD2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HEK293T cells. Antibodies: Affinity purified rabbit anti-PDCD2 antibody (Product # A303-598A) used for IP at 6 µg/mg lysate. PDCD2 was also immunoprecipitated by rabbit anti-PDCD2 antibody A303-599A, which recognizes a downstream epitope. For blotting immunoprecipitated PDCD2, A303-599A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 seconds.
Product Details
A303-598A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 150 and 200 of human Programmed Cell Death 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Programmed cell death protein 2; programmed cell death-2/Rp8 homolog; unnamed protein product; uS5 assembly chaperone PDCD2; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8
Gene Aliases: PDCD2; RP8; ZMYND7
UniProt ID: (Human) Q16342
Entrez Gene ID: (Human) 5134
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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