PA5-30256 targets PDCD2 in WB applications and shows reactivity with Human samples.
The PA5-30256 immunogen is recombinant fragment corresponding to a region within amino acids 113 and 344 of Human PDCD2.
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This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Two transcripts encoding different proteins have been identified.
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Protein Aliases: Programmed cell death protein 2; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8; ZMYND7
Gene Aliases: PDCD2; RP8; ZMYND7
UniProt ID: (Human) Q16342
Entrez Gene ID: (Human) 5134