Immunogen sequence: QSQVGFIDFI VEPTFTVLTD MTEKIVSPLI DETSQTGGTG QRRSSLNSIS SSDAKRSGVK TSGSEGSAPI NNSVISVDYK SFKATWTE
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 97%.
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin -dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 ).
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Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; 5' cyclic nucleotide phosphodiesterase (HSPDE1C1A); 5'-cyclic nucleotide phosphodiesterase 1C; calcium/calmodulin-dependent 3'; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; hCam-3; Hcam3; Human 3'; Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A); phosphodiesterase 1C, calmodulin-dependent 70kDa
Gene Aliases: cam-PDE 1C; hCam-3; Hcam3; PDE1C
UniProt ID: (Human) Q14123
Entrez Gene ID: (Human) 5137