FIGURE: 1 / 3
Recommended positive controls: A549, H1299, U87-MG, SK-N-SH, rat brain.
Predicted reactivity: Mouse (98%), Rat (97%), Xenopus laevis (89%), Pig (98%), Chicken (93%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DKFZp686F2182; DPDE4; dunce-like phosphodiesterase E4; MGC126529; MGC93193; OTTHUMP00000046896; PDE32; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); RP5-876C12.1
Gene Aliases: DPDE4; PDE4/IVb; PDE4B; Pde4B1; Pde4B2; Pde4B3; Pde4B4; PDEIVB
Molecular Function: phosphodiesterase