Search
Invitrogen
PDE4B Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5149682
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDE4B
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SGNQVSEYIS NTFLDKQNDV EIPSPTQKDR EKKKKQQLMT QISGVKKLMH SSSLNNTSIS RFGVNTENED HLAKELEDLN KWGLNIFNVA GYSHNRPLTC IMYAIFQERD LLKTFRISSD TFITYMMT
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase 4B; DKFZp686F2182; DPDE4; dunce-like phosphodiesterase E4; MGC126529; MGC93193; OTTHUMP00000046896; PDE32; PDE4B5; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); RP5-876C12.1; unnamed protein product
Gene Aliases: DPDE4; PDE4B; PDEIVB
UniProt ID: (Human) Q07343
Entrez Gene ID: (Human) 5142
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calcium channel regulator activity
protein binding
phosphoric diester hydrolase activity
hydrolase activity
cAMP binding
gamma-tubulin binding
ion channel binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
neutrophil homeostasis
cAMP catabolic process
signal transduction
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
T cell receptor signaling pathway
leukocyte migration
cellular response to lipopolysaccharide
cellular response to xenobiotic stimulus
cellular response to epinephrine stimulus
negative regulation of adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
negative regulation of cAMP/PKA signal transduction
negative regulation of relaxation of cardiac muscle
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support