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Fabgennix
PDE8B Polyclonal Antibody
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Product Details
PD8B-201AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic cyclic peptide common to all PDE8B variants.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5' cyclic nucleotide phosphodiesterase 8B; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; Cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B; HSPDE8B2; HSPDE8B3; PDE8B1; 3',5'-cyclic nucleotide phosphodiesterase; PIG22; unnamed protein product
Gene Aliases: ADSD; B230331L10Rik; C030047E14Rik; PDE8B; PIG22; PPNAD3; RNPDE8B
UniProt ID: (Human) O95263
Entrez Gene ID: (Human) 8622, (Rat) 309962, (Mouse) 218461
behavioral fear response
cAMP catabolic process
signal transduction
visual learning
operant conditioning
negative regulation of insulin secretion
neuromuscular process controlling balance
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade
negative regulation of steroid hormone biosynthetic process
negative regulation of cAMP/PKA signal transduction
phosphorelay signal transduction system
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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