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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the internal region of human PDEF (prostate-derived Ets factor).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||See 1 publications below|
PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer.
||Frietsch JJ,Grunewald TG,Jasper S,Kammerer U,Herterich S,Kapp M,Honig A,Butt E||British journal of cancer (102:1645)||2010|
PDEF; prostate epithelium-specific Ets transcription factor; prostate-derived Ets factor; Prostate-specific Ets; PSE; SPDEF
bA375E1.3; PDEF; PSE; SPDEF