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PDGF A Polyclonal Antibody

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PDGF A Polyclonal Antibody

Product Details

BS-10073R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-500
-

Immunocytochemistry (ICC/IF)

1:100-500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rabbit

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from rabbit PDGF-A (102-213).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.03% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PDGF A-chain; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A; unnamed protein product

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Gene Aliases: PDGF-1; PDGF-A; PDGF1; PDGFA

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UniProt ID: (Human) P04085, (Mouse) P20033

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Entrez Gene ID: (Rabbit) 100352388, (Human) 5154, (Mouse) 18590

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Function(s)
platelet-derived growth factor receptor binding protein binding collagen binding growth factor activity identical protein binding protein homodimerization activity protein heterodimerization activity receptor agonist activity platelet-derived growth factor binding growth factor
Process(es)
angiogenesis cell activation hair follicle development positive regulation of mesenchymal cell proliferation cell-cell signaling cell proliferation positive regulation of cell proliferation response to wounding organ morphogenesis negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation regulation of smooth muscle cell migration cell projection assembly actin cytoskeleton organization positive regulation of cell migration positive regulation of protein autophosphorylation regulation of actin cytoskeleton organization platelet-derived growth factor receptor-alpha signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway wound healing positive regulation of MAPK cascade skin development platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation lung alveolus development digestive tract development negative chemotaxis positive regulation of cell division positive regulation of protein kinase B signaling bone development regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling positive regulation of ERK1 and ERK2 cascade regulation of glomerular mesangial cell proliferation embryonic lung development regulation of DNA biosynthetic process multicellular organism development positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of MAP kinase activity positive regulation of DNA replication regulation of peptidyl-tyrosine phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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