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          • Primary Antibodies ›
          • PDGF-B Antibodies

          Bioss

          PDGF B Polyclonal Antibody

          View all (20) PDGF-B antibodies

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          Cite PDGF B Polyclonal Antibody

          Additional Information:

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          • Antibody Testing Data (2)
          PDGF B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          PDGF B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          PDGF B Antibody (BS-0185R) in IHC (P)

          Formalin-fixed and paraffin embedded rat transplant lymphoma labeled with Anti-PDGF-B Polyclonal Antibody, Unconjugated (bs-0185R) at 1:200 followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PDGF B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PDGF B Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          PDGF B Polyclonal Antibody

          Product Details

          BS-0185R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:300
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          Flow Cytometry (Flow)

          1:20-1:100
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human PDGF-B, amino acids 155-210.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: becaplermin; epididymis secretory sperm binding protein; orf 2; pdgf protein; PDGF subunit B; PDGF, B chain; PDGF-2; PDGF-B; PDGFB; platelet derived growth factor, B polypeptide; platelet derived growth factor-bb; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor, beta polypeptide (oncogene SIS); Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); proto-oncogene c-Sis; unnamed protein product

          View more View less

          Gene Aliases: c-sis; IBGC5; PDGF-2; PDGF-B; PDGF2; SIS; SSV

          View more View less

          UniProt ID: (Human) P01127, (Rat) Q05028, (Mouse) P31240

          View more View less

          Entrez Gene ID: (Human) 5155, (Rat) 24628, (Mouse) 18591

          View more View less

          Function(s)
          platelet-derived growth factor receptor binding protein binding collagen binding growth factor activity superoxide-generating NADPH oxidase activator activity chemoattractant activity identical protein binding protein homodimerization activity protein heterodimerization activity receptor agonist activity platelet-derived growth factor binding receptor binding
          Process(es)
          angiogenesis blood vessel development response to hypoxia embryonic placenta development positive regulation of endothelial cell proliferation monocyte chemotaxis positive regulation of glomerular filtration protein phosphorylation substrate-dependent cell migration cell communication synapse assembly heart development positive regulation of cell proliferation male gonad development response to xenobiotic stimulus response to wounding gene expression regulation of gene expression negative regulation of phosphatidylinositol biosynthetic process negative regulation of platelet activation positive regulation of gene expression negative regulation of gene expression positive regulation of cell-substrate adhesion positive regulation of smooth muscle cell migration neuron remodeling peptidyl-tyrosine phosphorylation glial cell development signaling actin cytoskeleton organization hemopoiesis positive regulation of cell migration negative regulation of cell migration response to estradiol response to insulin positive regulation of collagen biosynthetic process intracellular signal transduction interleukin-18-mediated signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus paracrine signaling regulation of cell proliferation eye photoreceptor cell development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration response to estrogen response to human chorionic gonadotropin positive regulation of DNA replication positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle, embryonic platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation blood vessel morphogenesis positive regulation of smooth muscle cell proliferation response to axon injury regulation of peptidyl-tyrosine phosphorylation positive chemotaxis positive regulation of chemotaxis regulation of multicellular organismal process myoblast proliferation positive regulation of protein kinase B signaling retina development in camera-type eye cell chemotaxis branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to mycophenolic acid positive regulation of glomerular mesangial cell proliferation metanephric glomerular mesangial cell development metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular endothelium development reactive oxygen species metabolic process positive regulation of calcium ion import positive regulation of hyaluronan biosynthetic process positive regulation of intracellular signal transduction negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter cellular response to angiotensin positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration positive regulation of hepatic stellate cell proliferation negative regulation of vascular smooth muscle cell differentiation positive regulation of vascular smooth muscle cell dedifferentiation response to quercetin positive regulation of reactive oxygen species metabolic process positive regulation of hepatic stellate cell activation positive regulation of DNA biosynthetic process positive regulation of metanephric mesenchymal cell migration vasoconstriction positive regulation of vasoconstriction cardiac vascular smooth muscle cell differentiation smooth muscle adaptation
          It has to be done as per old AB suggested Products section.

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