PA5-16576 targets PDGFR beta in IHC (P) applications and shows reactivity with mouse and Human samples.
The PA5-16576 immunogen is a synthetic peptide derived from near the C-terminus of human PDGFR, beta.
PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. They possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind autophosphorylate and activate only PDGFR, alpha while PDGF BB can bind and activate to both PDGFR, alpha and beta.
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Protein Aliases: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; JTK12; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR; PDGFR-1; PDGFR-beta; PDGFR1; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; platelet-derived growth factor receptor, beta polypeptide
Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT