Proteintech

PDSS2 Polyclonal Antibody

PDSS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PDSS2 Antibody (13544-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 13544-1-AP (PDSS2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

13544-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PDSS2 Fusion Protein Ag4487 (1-242 aa encoded by BC039906)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

PDSS2 has 2 isoforms with MW of 44 kDa and 27 kDa while 13544-1-AP antibody detects the bands around 27-30 kDa and 44-47 kDa in SDS-PAGE.

Immunogen sequence: MNFRQLLLH LPRYLGASGS PRRLWWSPSL DTISSVGSWR GRSSKSPAHW NQVVSEAEKI VGYPTSFMSL RCLLSDELSN IAMQVRKLVG TQHPLLTTAR GLVHDSWNSL QLRGLVVLLI SKAAGPSSVN TSCQNYDMVS GIYSCQRSLA EITELIHIAL LVHRGIVNLN ELQSSDGPLK DMQFGNKIAI LSGDFLLANA CNGLALLQNT KVVELLASAL MDLVQGVYHE NSTSKESYIT DDI (1-242 aa encoded by BC039906)

Target Information

The isoprenoid chain of ubiquinone (coenzyme Q) varies in length between species and is determined by trans-polyprenyl diphosphate synthase. Humans possess a heterotetrameric decaprenyl diphosphate synthase composed of DPS1 and DLP1 (PDSS2) that produces Q10 ubiquinone.The isoprenoid chain of ubiquinone (coenzyme Q) varies in length between species and is determined by trans-polyprenyl diphosphate synthase. Humans possess a heterotetrameric decaprenyl diphosphate synthase composed of DPS1 and DLP1 (PDSS2) that produces Q10 ubiquinone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy.

Neurology. Genetics

Smith IC,Pileggi CA,Wang Y,Kernohan K,Hartley T,McMillan HJ,Sampaio ML,Melkus G,Woulfe J,Parmar G,Bourque PR,Breiner A,Zwicker J,Pringle CE,Jarinova O,Lochmüller H,Dyment DA,Brais B,Boycott KM,Hekimi S,Harper ME,Warman-Chardon J

Wed Feb 01 00:00:00 UTC 2023

A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options.

Molecular genetics and metabolism reports

Wang Y,Gumus E,Hekimi S

Wed Jun 01 00:00:00 UTC 2022

The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains functional by metalation with cobalt.

microPublication biology

Wang Y,Hekimi S

Sat Oct 01 00:00:00 UTC 2022

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 UTC 2019

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 UTC 2019

Co-Enzyme Q10 Supplementation Rescues Cumulus Cells Dysfunction in a Maternal Aging Model.

Antioxidants (Basel, Switzerland)

Ben-Meir A,Kim K,McQuaid R,Esfandiari N,Bentov Y,Casper RF,Jurisicova A

Fri Mar 08 00:00:00 UTC 2019

What maintains the high intra-follicular estradiol concentration in pre-ovulatory follicles?

Journal of assisted reproduction and genetics

Bentov Y,Jurisicova A,Kenigsberg S,Casper RF

Fri Jan 01 00:00:00 UTC 2016

What maintains the high intra-follicular estradiol concentration in pre-ovulatory follicles?

Journal of assisted reproduction and genetics

Bentov Y,Jurisicova A,Kenigsberg S,Casper RF

Fri Jan 01 00:00:00 UTC 2016

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Aging cell

Ben-Meir A,Burstein E,Borrego-Alvarez A,Chong J,Wong E,Yavorska T,Naranian T,Chi M,Wang Y,Bentov Y,Alexis J,Meriano J,Sung HK,Gasser DL,Moley KH,Hekimi S,Casper RF,Jurisicova A

Thu Oct 01 00:00:00 UTC 2015

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Aging cell

Ben-Meir A,Burstein E,Borrego-Alvarez A,Chong J,Wong E,Yavorska T,Naranian T,Chi M,Wang Y,Bentov Y,Alexis J,Meriano J,Sung HK,Gasser DL,Moley KH,Hekimi S,Casper RF,Jurisicova A

Thu Oct 01 00:00:00 UTC 2015

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Aging cell

Ben-Meir A,Burstein E,Borrego-Alvarez A,Chong J,Wong E,Yavorska T,Naranian T,Chi M,Wang Y,Bentov Y,Alexis J,Meriano J,Sung HK,Gasser DL,Moley KH,Hekimi S,Casper RF,Jurisicova A

Thu Oct 01 00:00:00 UTC 2015

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Aging cell

Ben-Meir A,Burstein E,Borrego-Alvarez A,Chong J,Wong E,Yavorska T,Naranian T,Chi M,Wang Y,Bentov Y,Alexis J,Meriano J,Sung HK,Gasser DL,Moley KH,Hekimi S,Casper RF,Jurisicova A

Thu Oct 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: All trans-polyprenyl-diphosphate synthase PDSS2; All-trans-decaprenyl-diphosphate synthase subunit 2; Candidate tumor suppressor protein; Decaprenyl pyrophosphate synthase subunit 2; decaprenyl pyrophosphate synthetase subunit 2; Decaprenyl-diphosphate synthase subunit 2; prenyl (solanesyl) diphosphate synthase, subunit 2; prenyltransferase-like mitochondrial protein; RP11-59I9.3; Solanesyl-diphosphate synthase subunit 2; subunit 2 of decaprenyl diphosphate synthase

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Gene Aliases: 5430420P03Rik; bA59I9.3; C6orf210; COQ10D3; DLP1; Gm60; hDLP1; kd; mDLP1; PDSS2; Plmp

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UniProt ID: (Human) Q86YH6, (Rat) Q5U2R1, (Mouse) Q33DR3

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Entrez Gene ID: (Human) 57107, (Rat) 365592, (Mouse) 71365

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Function(s)

trans-hexaprenyltranstransferase activity protein heterodimerization activity trans-octaprenyltranstransferase activity transferase activity

Process(es)

ubiquinone biosynthetic process isoprenoid biosynthetic process regulation of body fluid levels protein heterotetramerization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PDSS2 Polyclonal Antibody

PDSS2 Antibody (13544-1-AP) in IHC (P)

Product Details

13544-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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