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Proteintech
PDZK1 Polyclonal Antibody
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Product Details
10507-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PDZK1 Fusion Protein Ag0787 (1-300 aa encoded by BC006496)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTSTFNPRE CKLSKQEGQN YGFFLRIEKD TEGHLVRVVE KCSPAEKAGL QDGDRVLRIN GVFVDKEEHM QVVDLVRKSG NSVTLLVLDG DSYEKAVKTR VDLKELGQSQ KEQGLSDNIL SPVMNGGVQT WTQPRLCYLV KEGGSYGFSL KTVQGKKGVY MTDITPQGVA MRAGVLADDH LIEVNGENVE DASHEEVVEK VKKSGSRVMF LLVDKETDKR HVEQKIQFKR ETASLKLLPH QPRIVEMKKG SNGYGFYLRA GSEQKGQIIK DIDSGSPAEE AGLKNNDLVV AVNGESVETL D (1-300 aa encoded by BC006496)
Target Information
PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-terminal linking and modulating protein; C-terminal-linking and modulating protein; CFTR-associated protein of 70 kDa; Dietary Pi-regulated RNA-1; Diphor-1; Na(+)/H(+) exchange regulatory cofactor 3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-C; NaPi-Cap1; NHERF-3; PDZ domain-containing protein 1; PDZ-containing kidney protein 1; PDZK 1; PDZK-1; Sodium-hydrogen exchanger regulatory factor 3; unnamed protein product
Gene Aliases: 1700023D20Rik; 2610507N21Rik; 4921513F16Rik; AI267131; AI314638; AL022680; CAP70; CLAMP; D3Ertd537e; Diphor1; mPDZK1; NHERF-3; NHERF3; PDZD1; PDZK1
UniProt ID: (Human) Q5T2W1, (Mouse) Q9JIL4, (Rat) Q9JJ40
Entrez Gene ID: (Human) 5174, (Mouse) 59020, (Rat) 65144
regulation of anion transport
protein localization to plasma membrane
positive regulation of protein targeting to membrane
carnitine transmembrane transport
positive regulation of protein localization to membrane
drug transmembrane export
transport
carnitine transport
positive regulation of ion transmembrane transport
establishment of protein localization to plasma membrane
cholesterol transport
intracellular transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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