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Invitrogen
PHD4 Polyclonal Antibody
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Product Details
PA1-32331
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a portion of the C-terminus
of the human prolyl hydroxylase domain-containing 4
encoded within exon 4. [LocusLink 54681]
of the human prolyl hydroxylase domain-containing 4
encoded within exon 4. [LocusLink 54681]
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
Product Specific Information
PA1-32331 detects PHD4 from human samples.
PA1-32331 has been successfully used in Western blot applications.
The PA1-32331 immunogen is: Synthetic peptide corresponding to a portion of the C-terminus of the human prolyl hydroxylase domain-containing 4 encoded within exon 4. [LocusLink 54681].
Target Information
Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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