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Active Motif
PHF8 Polyclonal Antibody
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Product Details
39711
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This PHF8 antibody was raised against a synthetic peptide derived from human PHF8.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PHD finger protein 8 is a jumonji domain containing protein. Like other members of the jumonji family, PHF8 may therefore play a role in histone demethylation. Mutations in PHF8 lead to Siderius type X-linked mental retardation (MRXSSD), a mild to borderline type of mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8; Histone lysine demethylase PHF8; jumonji C domain-containing histone demethylase 1F; Lysine demethylase 7B; PHD finger protein 8; unnamed protein product; zinc finger protein 422
Gene Aliases: JHDM1F; KDM7B; KIAA1111; MRXSSD; PHF8; ZNF422
UniProt ID: (Human) Q9UPP1
Entrez Gene ID: (Human) 23133
chromatin binding
transcription cofactor activity
iron ion binding
protein binding
zinc ion binding
oxidoreductase activity
histone demethylase activity
histone demethylase activity (H3-K9 specific)
histone demethylase activity (H4-K20 specific)
metal ion binding
dioxygenase activity
histone demethylase activity (H3-K36 specific)
histone demethylase activity (H3-K27 specific)
histone H3K4me3 reader activity
histone H3-di/monomethyl-lysine-36 demethylase activity
histone H3K9me/H3K9me2 demethylase activity
G1/S transition of mitotic cell cycle
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
brain development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
negative regulation of chromatin silencing at rDNA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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