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FIGURE: 1 / 3
Positive test controls include: HeLa, SH-SY5Y, Mouse testis, Mouse brain, Rat testis, Rat brain. The target is usually found in the following locations: Cell membrane, Cytoplasm, Membrane, Nucleus, Peripheral membrane protein.
Immunogen sequence: DQPSTGDASG APAVWSHGYT EASGVKNKLC VAALSVNNFC DNREALYGVF DGDRNVEVPY LLQCTMSDIL AEELQKTKNE EEYMVNTFIV MQRKLGTAGQ KLGGAAVLCH IKHDPVDPGG SFTLTSANVG KCQTVLCRNG KPLPLSRSYI MSCEEELKRI KQHKAIITED GKVNGVTEST RILGYTFLHP SVVPRPHVQS VLLTPQDEFF ILGSKGLWDS LSVEEAVEAV RNVPDALAAA KKLCTLAQSY GCHDSISAVV VQLSVTEDS
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
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Protein Aliases: Circadian Oscillatory Protein (SCOP); EC 3.1.3.16; hSCOP; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; Pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; Suprachiasmatic nucleus circadian oscillatory protein
Gene Aliases: AI836256; KIAA0606; mKIAA0606; PHLPP; PHLPP1; PLEKHE1; PPM3A; SCOP
UniProt ID: (Human) O60346, (Mouse) Q8CHE4, (Rat) Q9WTR8
Entrez Gene ID: (Human) 23239, (Mouse) 98432, (Rat) 59265
Molecular Function: scaffold/adaptor protein
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