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Invitrogen
PIAS2 Polyclonal Antibody
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FIGURE: 1 / 1
PIAS2 Antibody (PA5-86254) in WB
Western blot analysis of PIAS2 in Lane 1: MCF-7 whole cell lysate (40 µg), Lane 2: HepG2 whole cell lysate (40 µg), Lane 3: PC3 whole cell lysate (40 µg), Lane 4: Testis tissue lysate of mouse (40 µg), Lane 5: rat testis tissue lysate (40 µg). Sample was incubated with PIAS2 polyclonal antibody (Product # PA5-86254) using a 1:500 dilution.
Product Details
PA5-86254
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 1-50 of Human PIASx.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS2; MGC102682; Miz1; Msx-interacting zinc finger protein; Msx-interacting-zinc finger; Msx-interacting-zinc finger protein; PIAS-NY protein; PIASxalpha6; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2; RING-type E3 ubiquitin transferase PIAS2; unnamed protein product; zinc finger, MIZ-type containing 4
Gene Aliases: 6330408K17Rik; AI462206; ARIP3; AU018068; Dib; DIP; MIZ1; PIAS2; PIASX; PIASxalpha; PIASxb; PIASxbeta; SIZ2; ZMIZ4
UniProt ID: (Human) O75928, (Rat) Q6AZ28, (Mouse) Q8C5D8
Entrez Gene ID: (Human) 9063, (Rat) 83422, (Mouse) 17344
DNA binding
transcription cofactor activity
transcription corepressor activity
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
ubiquitin protein ligase binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
SUMO ligase activity
transcription factor binding
ligase activity
protein domain specific binding
estrogen receptor binding
glucocorticoid receptor binding
androgen receptor binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
metabolic process
response to organic substance
protein sumoylation
androgen receptor signaling pathway
response to testosterone
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of dendrite morphogenesis
regulation of androgen receptor signaling pathway
negative regulation of androgen receptor signaling pathway
transforming growth factor beta receptor signaling pathway
endoplasmic reticulum unfolded protein response
negative regulation of transcription, DNA-templated
regulation of macromolecule metabolic process
SMAD protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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