Immunogen sequence: KELDEIIMQT AEIENEDEAE RVLFSYGYGA NVPTTAKRRL KQSVHLARRV LQLEKQNSLI LKDLEHRKDQ VTQLSQELDR ANSLLNQTQQ PYRYLIESV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 91%.
PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.
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Protein Aliases: C13orf24; Centrosomal protein of 90 kDa; CEP90; PIBF; progesterone-induced blocking factor 1; Progesterone-induced-blocking factor 1; RP11-505F3.1
Gene Aliases: C13orf24; CEP90; PIBF; PIBF1
UniProt ID: (Human) Q8WXW3
Entrez Gene ID: (Human) 10464