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Proteintech
PIG3 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-14828
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PIG3 fusion protein Ag6618
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MLAVHFDKP GGPENLYVKE VAKPSPGEGE VLLKVAASAL NRADLMQRQG QYDPPPGASN ILGLEASGHV AELGPGCQGH WKIGDTAMAL LPGGGQAQYV TVPEGLLMPI PEGLTLTQAA AIPEAWLTAF QLLHLVGNVQ AGDYVLIHAG LSGVGTAAIQ LTRMAGAIPL VTAGSQKKLQ MAEKLGAAAG FNYKKEDFSE ATLKFTKGAG VNLILDCIGG SYWEKNVNCL ALDGRWVLYG LMGGGDINGP LFSKLLFKRG SLITSLLRSR DNKYKQMLVN AFTEQILPHF STEGPQRLLP VLDRIYPVTE IQEAHKYMEA NKNIGKIVLE LPQ
Target Information
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NADPH:quinone reductase PIG3; p53-induced gene 3 protein; Protein PIG3; quinone oxidoreductase homolog; Quinone oxidoreductase PIG3; Tumor protein p53-inducible protein 3
Gene Aliases: PIG3; TP53I3
UniProt ID: (Human) Q53FA7
Entrez Gene ID: (Human) 9540
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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