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Proteintech
PIK3C2A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
22028-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PIK3C2A Fusion Protein Ag16894 (1-338 aa encoded by BC113658)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAQISSNSG FKECPSSHPE PTRAKDVDKE EALQMEAEAL AKLQKDRQVT DNQRGFELSS STRKKAQVYN KQDYDLMVFP ESDSQKRALD IDVEKLTQAE LEKLLLDDSF ETKKTPVLPV TPILSPSFSA QLYFRPTIQR GQWPPGLPGP STYALPSIYP STYSKQAAFQ NGFNPRMPTF PSTEPIYLSL PGQSPYFSYP LTPATPFHPQ GSLPIYRPVV STDMAKLFDK IASTSEFLKN GKARTDLEIT DSKVSNLQVS PKSEDISKFD WLDLDPLSKP KVDNVEVLDH EEEKNVSSLL AKDPWDAVLL EERSTANCHL ERKVNGKSLS VATVTRSQS (1-338 aa encoded by BC113658 )
Target Information
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enyzmes have been linked to diverse, receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C2-containing phosphatidylinositol kinase; DKFZp686L193; MGC142218; p170; phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphoinositide 3-kinase-C2-alpha; phosphoinositide-3-kinase, class 2, alpha polypeptide; PI3K-C2-alpha; pi3kc2a; ptdIns-3-kinase C2 subunit alpha; unnamed protein product
Gene Aliases: CPK; Cpk-m; OCSKD; PI3-K-C2(ALPHA); PI3-K-C2A; PI3K-C2-alpha; PI3K-C2alpha; PI3KC2
UniProt ID: (Human) O00443, (Mouse) Q61194
Entrez Gene ID: (Human) 5286, (Mouse) 18704
phosphatidylinositol biosynthetic process
exocytosis
endocytosis
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
positive regulation of autophagy
vascular smooth muscle contraction
cell migration
phosphatidylinositol-3-phosphate biosynthetic process
protein kinase B signaling
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
clathrin coat assembly
membrane organization
positive regulation of cell migration involved in sprouting angiogenesis
cellular response to starvation
macroautophagy
negative regulation of zinc ion transmembrane transport
autophagosome organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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