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PIK3C3 Polyclonal Antibody
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FIGURE: 1 / 1
PIK3C3 Antibody (600-401-DN6) in WB
Western Blot of Rabbit anti-PIK3C3 antibody. Lane A: mouse small intestine tissue lysate. Primary antibody: PIK3C3 antibody at 1 µg/mL overnight at 4°C. Secondary antibody: Goat anti-Rabbit HRP secondary antibody. Block: 5% BLOTTO. Predicted/Observed size: 91/98 kDa, 98 kDa for PIK3C3.
Product Details
600-401-DN6
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-PIK3C3 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the N-terminus of human PIK3C3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PIK3C3 (hVPS34) is the sole class III member of the PI3 Kinase family. PIK3C3 phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PI(3)P], which recruits downstream effectors containing FYVE and Phox domains to membranes. PIK3C3 is involved in coupling nutrient signaling to mTOR and also plays a role in autophagy and intracellular trafficking. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: catalytic phosphatidylinositol 3-kinase 3; catalytic subunit type 3 Antibody; Class III PI 3-kinase; hVps34; hVps34 Antibody; OTTMUSP00000023341; OTTMUSP00000023350; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI-3K Vps34p; PI3-kinase type 3; PI3K type 3; pi3kc3; PIK3C3 Antibody; PtdIns-3-kinase type 3; unnamed protein product; vacuolar protein sorting 34 homolog
Gene Aliases: 5330434F23Rik; hVps34; PIK3C3; VPS34
UniProt ID: (Human) Q8NEB9, (Rat) O88763, (Mouse) Q6PF93
Entrez Gene ID: (Human) 5289, (Rat) 65052, (Mouse) 225326
nucleotide binding
protein kinase activity
protein binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
transferase activity
phosphotransferase activity, alcohol group as acceptor
phosphatidylinositol kinase activity
phosphatidylinositol 3-kinase activity
transferase activity, transferring phosphorus-containing groups
kinase
autophagosome assembly
pexophagy
protein targeting to lysosome
lipid metabolic process
endocytosis
autophagy
endosome organization
cellular response to starvation
regulation of autophagy
macroautophagy
regulation of macroautophagy
protein processing
regulation of cytokinesis
protein localization to pre-autophagosomal structure
phosphatidylinositol-3-phosphate biosynthetic process
cellular response to glucose starvation
response to leucine
protein kinase B signaling
positive regulation by host of viral genome replication
early endosome to late endosome transport
positive regulation of natural killer cell mediated cytotoxicity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
synaptic vesicle endocytosis
cell division
interferon-gamma-mediated signaling pathway
interleukin-6-mediated signaling pathway
autophagosome maturation
positive regulation of protein lipidation
protein phosphorylation
regulation of protein secretion
cytokinesis
cell cycle
endosomal transport
phosphorylation
pexophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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