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Invitrogen

PIK3CA Polyclonal Antibody

View all (24) PIK3CA antibodies

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PIK3CA Polyclonal Antibody

Product Details

PA5-88576

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human PIK3CA (NP_0062092)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Amount

34 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805007

Product Specific Information

Positive Samples: Mouse kidney

Immunogen sequence: DCFTMPSYSR RISTATPYMN GETSTKSLWV INSALRIKIL CATYVNVNIR DIDKIYVRTG IYHGGEPLCD NVNTQRVPCS NPRWNEWLNY DIYIPDLPRA ARLCLSICSV KGRKGAKEEH CPLAWGNINL FDYTDTLVSG KMALNLWPVP HGLEDLLNPI GVTGSNPNKE TPCLELEFDW FSSVVKFPDM SVIEEHANWS VSREAGFSYS HAGLSNRLAR DNELRENDKE QLKAISTRDP LSEITEQEKD FLWSHRHYCV TIPEILPKLL LSVKWNSRDE VAQMYCLVKD WPPIKPEQAM E

Target Information

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; PI3K-alpha; PI3Kalpha; pi3kca; PIK3R1; pk3ca; ptdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA; unnamed protein product

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Gene Aliases: 6330412C24Rik; caPI3K; CCM4; CLAPO; CLOVE; CWS5; HMH; MCAP; MCM; MCMTC; p110; p110-alpha; p110alpha; PI3K; PI3K-alpha; PIK3CA

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UniProt ID: (Human) P42336, (Mouse) P42337, (Rat) A0A0G2K344

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Entrez Gene ID: (Human) 5290, (Mouse) 18706, (Rat) 170911

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Function(s)
nucleotide binding protein serine/threonine kinase activity protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity transferase activity protein kinase activator activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein serine kinase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor kinase
Process(es)
angiogenesis liver development vasculature development glucose metabolic process lipid metabolic process phagocytosis epidermal growth factor receptor signaling pathway insulin receptor signaling pathway regulation of gene expression positive regulation of lamellipodium assembly negative regulation of gene expression response to activity response to muscle inactivity negative regulation of macroautophagy cell migration actin cytoskeleton organization platelet activation negative regulation of actin filament depolymerization positive regulation of TOR signaling cellular response to insulin stimulus response to muscle stretch phosphatidylinositol-3-phosphate biosynthetic process vascular endothelial growth factor signaling pathway regulation of multicellular organism growth response to leucine anoikis regulation of cellular respiration protein kinase B signaling negative regulation of neuron apoptotic process endothelial cell migration phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation T cell receptor signaling pathway positive regulation of protein kinase B signaling relaxation of cardiac muscle cardiac muscle contraction adipose tissue development cellular response to glucose stimulus cellular response to hydrostatic pressure response to dexamethasone cardiac muscle cell contraction energy homeostasis regulation of actin filament organization autosome genomic imprinting response to butyrate positive regulation of protein localization to membrane negative regulation of fibroblast apoptotic process negative regulation of anoikis adaptive immune response protein phosphorylation inflammatory response phosphatidylinositol 3-kinase signaling phosphorylation positive regulation of peptidyl-serine phosphorylation hypomethylation of CpG island innate immune response positive regulation of protein kinase activity cell chemotaxis mitophagy in response to mitochondrial depolarization regulation of genetic imprinting
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