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Invitrogen
PIK3CG Polyclonal Antibody
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Product Details
PA5-28070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PI3 kinase p110 gamma. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 40% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: PIK3CG-transfected 293T, Neuro 2A, Raw264.7, C8D30, PC-12.
Predicted reactivity: Mouse (100%), Pig (100%), Rhesus Monkey (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1-phosphatidylinositol 3-kinase; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3-kinase subunit gamma; PI3K-gamma; pi3kcg; ptdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG
Gene Aliases: 5830428L06Rik; p110gamma; p120-PI3K; PI3CG; PI3K; Pi3kg1; PI3Kgamma; PIK3; PIK3CG
UniProt ID: (Human) P48736, (Mouse) Q9JHG7
Entrez Gene ID: (Human) 5294, (Mouse) 30955, (Rat) 298947
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol 3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
angiogenesis
cytokine production
adaptive immune response
dendritic cell chemotaxis
positive regulation of acute inflammatory response
respiratory burst involved in defense response
protein phosphorylation
phosphatidylinositol biosynthetic process
endocytosis
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
T cell chemotaxis
negative regulation of triglyceride catabolic process
phosphatidylinositol 3-kinase signaling
platelet activation
neutrophil chemotaxis
secretory granule localization
regulation of cell adhesion mediated by integrin
natural killer cell chemotaxis
phosphatidylinositol-3-phosphate biosynthetic process
T cell proliferation
T cell activation
mast cell degranulation
positive regulation of MAP kinase activity
innate immune response
phosphatidylinositol phosphorylation
positive regulation of protein kinase B signaling
negative regulation of cardiac muscle contraction
platelet aggregation
cellular response to cAMP
neutrophil extravasation
hepatocyte apoptotic process
regulation of calcium ion transmembrane transport
negative regulation of fibroblast apoptotic process
regulation of protein phosphorylation
immune system process
chemotaxis
phosphorylation
positive regulation of catalytic activity
phosphatidylinositol-mediated signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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