Invitrogen

PIK3CG Polyclonal Antibody

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PIK3CG Polyclonal Antibody

Product Details

PA5-87399

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human PIK3CG (NP_0026402)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804119

Product Specific Information

Immunogen sequence: MELENYKQPV VLREDNCRRR RRMKPRSAAA SLSSMELIPI EFVLPTSQRK CKSPETALLH VAGHGNVEQM KAQVWLRALE TSVAADFYHR LGPHHFLLLY QKKGQWYEIY DKYQVVQTLD CLRYWKATHR SPGQIHLVQR HPPSEESQAF QRQLTALIGY DVTDVSNVHD DELEFTRRGL VTPRMAEVAS RDPKLYAMHP WVTSKPLPEY LWKKIANNCI FIVIHRSTTS QTIKVSPDDT PGAILQSFFT KMAKKKSLMD IPESQSEQDF VLRVCGRDEY LVGETPIKNF QWVRHCLKNG EEIHVVLDTP; Positive Samples: HeLa; Cellular Location: Cell membrane, Cytoplasm

Target Information

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidylinositol 3-kinase; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; PI3-kinase subunit gamma; pi3kcg; ptdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG

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Gene Aliases: p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3; PIK3CG

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UniProt ID: (Human) P48736

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Entrez Gene ID: (Human) 5294

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein binding ATP binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity kinase
Process(es)
angiogenesis cytokine production adaptive immune response dendritic cell chemotaxis positive regulation of acute inflammatory response respiratory burst involved in defense response protein phosphorylation phosphatidylinositol biosynthetic process endocytosis inflammatory response G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration T cell chemotaxis negative regulation of triglyceride catabolic process phosphatidylinositol 3-kinase signaling platelet activation neutrophil chemotaxis secretory granule localization regulation of cell adhesion mediated by integrin natural killer cell chemotaxis phosphatidylinositol-3-phosphate biosynthetic process T cell proliferation T cell activation mast cell degranulation positive regulation of MAP kinase activity innate immune response phosphatidylinositol phosphorylation positive regulation of protein kinase B signaling negative regulation of cardiac muscle contraction platelet aggregation cellular response to cAMP neutrophil extravasation hepatocyte apoptotic process regulation of calcium ion transmembrane transport negative regulation of fibroblast apoptotic process
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