Invitrogen

PIK3R2 Polyclonal Antibody

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Antibody Testing Data (3)
Published Figures (2)

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PIK3R2 Antibody (PA5-84807) in WB

Western blot analysis of PI3K p85 beta by a PI3K p85 beta polyclonal antibody (Product # PA5-84807). Analysis in human cell line RT-4 and human cell line U-251 MG.

Product Image Gallery

PIK3R2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of PI3K p85 beta in U-2 OS cells using a PI3K p85 beta polyclonal antibody (Product # PA5-84807). The analysis shows localization to the Golgi apparatus.

PIK3R2 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of PI3K p85 beta in human duodenum using a PI3K p85 beta polyclonal antibody (Product # PA5-84807). The analysis shows strong cytoplasmic positivity in glandular cells.

Product Details

PA5-84807

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PI3K p85 beta

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Anitgen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2791956

Product Specific Information

Immunogen sequence: EMQRILLNSE RLKSRIAEIH ESRTKLEQQL RAQASDN

Target Information

Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Efficient Delivery of Triptolide Plus a miR-30-5p Inhibitor Through the Use of Near Infrared Laser Responsive or CADY Modified MSNs for Efficacy in Rheumatoid Arthritis Therapeutics.

Frontiers in bioengineering and biotechnology

Zhang X,Zhang X,Wang X,Wang T,Bai B,Zhang N,Zhao Y,Yu Y,Wang B

PA5-84807 was used in Western Blot to provide a novel understanding of RA pathogenesis and a theoretical basis for RA treatment.

Mon Sep 28 00:00:00 EDT 2020

Efficient Delivery of Triptolide Plus a miR-30-5p Inhibitor Through the Use of Near Infrared Laser Responsive or CADY Modified MSNs for Efficacy in Rheumatoid Arthritis Therapeutics.

Frontiers in bioengineering and biotechnology

Zhang X,Zhang X,Wang X,Wang T,Bai B,Zhang N,Zhao Y,Yu Y,Wang B

PA5-84807 was used in Western Blot to provide a novel understanding of RA pathogenesis and a theoretical basis for RA treatment.

Mon Sep 28 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K; PI3K regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta

Gene Aliases: MPPH; MPPH1; p85; p85-BETA; P85B; PIK3R2

UniProt ID: (Human) O00459

Entrez Gene ID: (Human) 5296

Molecular Function: kinase modulator

Function(s)

cellular glucose homeostasis phosphatidylinositol biosynthetic process insulin receptor signaling pathway regulation of autophagy phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling protein transport cellular response to insulin stimulus response to endoplasmic reticulum stress phosphatidylinositol-3-phosphate biosynthetic process Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of transcription factor import into nucleus positive regulation of GTPase activity regulation of phosphatidylinositol 3-kinase activity positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration regulation of small GTPase mediated signal transduction positive regulation of glucose import in response to insulin stimulus

Process(es)

GTPase activator activity protein binding 1-phosphatidylinositol-3-kinase activity protein phosphatase binding receptor tyrosine kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity

PIK3R2 Polyclonal Antibody

PIK3R2 Antibody (PA5-84807) in WB

Product Details

PA5-84807

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

RRID

Product Specific Information

Target Information

Bioinformatics

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