Invitrogen

PINK1 Polyclonal Antibody

View all (28) PINK1 antibodies

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PINK1 Antibody in Western Blot (WB) — Western Blot staining of Rat Testis lysate using Product # PA5-18770 at a concentration of 1.0 µg/mL, the primary antibody incubation was 1 hour and the detection method was chemiluminescence.

Product Details

PA5-18770

Applications	Tested Dilution	Publications
Western Blot (WB)	1-3 µg/mL	-

Product Specifications
Species Reactivity	Rat
Host/Isotype	Goat / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide sequence (QGKAHLESRSYQEAQ) corresponding to the internal amino acids of PINK1 View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	TBS, pH 7.3, with 0.5% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_10989348

Product Specific Information

This antibody is predicted to react with human and mouse based on sequence homology.

Target Information

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ27236; PINK 1; PINK-1; serine/threonine-protein kinase PINK1, mitochondrial

Entrez Gene ID: (Rat) 298575

Molecular Function: non-receptor serine/threonine protein kinase protein modifying enzyme

mitophagy positive regulation of protein phosphorylation protein phosphorylation response to oxidative stress mitochondrion organization biological_process regulation of hydrogen peroxide metabolic process negative regulation of gene expression negative regulation of macroautophagy protein ubiquitination peptidyl-serine phosphorylation respiratory electron transport chain regulation of protein ubiquitination positive regulation of synaptic transmission, dopaminergic positive regulation of peptidyl-serine phosphorylation positive regulation of dopamine secretion positive regulation of catecholamine secretion cellular response to oxidative stress positive regulation of protein dephosphorylation intracellular signal transduction regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of translation protein stabilization positive regulation of sequence-specific DNA binding transcription factor activity regulation of mitochondrial membrane potential cellular response to hypoxia positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission cellular response to toxic substance negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of autophagosome assembly negative regulation of mitophagy negative regulation of oxidative stress-induced cell death regulation of protein targeting to mitochondrion negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway positive regulation of cristae formation regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process

Process(es)

magnesium ion binding protease binding molecular_function protein serine/threonine kinase activity protein binding ATP binding calcium-dependent protein kinase activity kinase activity ubiquitin protein ligase binding protein kinase B binding C3HC4-type RING finger domain binding