Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1-3 µg/mL | - |
Product Specifications | |
---|---|
Species Reactivity |
Rat |
Host/Isotype |
Goat / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide sequence (QGKAHLESRSYQEAQ) corresponding to the internal amino acids of PINK1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
TBS, pH 7.3, with 0.5% BSA |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_10989348 |
This antibody is predicted to react with human and mouse based on sequence homology.
PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ27236; PINK 1; PINK-1; serine/threonine-protein kinase PINK1, mitochondrial
Entrez Gene ID: (Rat) 298575
Molecular Function:
non-receptor serine/threonine protein kinase
protein modifying enzyme
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