Immunogen sequence: RPSFYAERFF KFMSNTVFRK NSSLKSSPSK KGRGGALLAV KPLGPTAAFS ASQIPSEREE AQYDLRGARS YPTLEDEGRP DLLPCTPPSF EEATTASIAT TLSSTSLSIP ERS
Phosphatidylinositol-4-phosphate-5-kinase (PIPK) synthesizes phosphatidylinositol-4,5-bisphosphate, which regulates various processes including cell proliferation, survival, membrane trafficking and cytoskeletal organization. The PIPK family is divided into type I, type II and type III. Each type of the PIPK family phosphorylates distinct substrates. They contain an activation loop, which determines their enzymatic specificity and subcellular targeting. The phosphatidylinositol-4-phosphate-5-kinase type I consists of three members, PIPK I alpha, beta and gamma, which are characterized by phosphorylating PI4P on the 5-hydroxyl. PIPK I alpha, designated PIPK I beta in mouse, is expressed in brain tissue. PIPK I beta, designated PIPK I alpha in mouse, is also called STM7. PIPK I gamma has two variants produced by alternative splicing which are expressed in lung, brain and kidneys.
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Protein Aliases: diphosphoinositide kinase; KIAA0589; LCCS3; Phosphatidylinositol 4-phosphate 5-kinase type I gamma; Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; PIP5K1-gamma; PIP5Kgamma; PIP5KIgamma; ptdIns(4)P-5-kinase 1 gamma; type I PIP kinase
Gene Aliases: KIAA0589; LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5K1C; PIP5Kgamma
UniProt ID: (Human) O60331
Entrez Gene ID: (Human) 23396