Keep as concentrated solution.
Predicted reactivity: Mouse (96%), Rat (95%), Zebrafish (87%), Japanese Medaka (86%), Xenopus laevis (88%), Pig (97%), Chicken (93%), Bovine (97%).
Positive Control: PITX2-transfected 293T cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: all1-responsive gene 1; all1-responsive gene 1 antibody; ALL1-responsive protein ARP1; ALL1-responsive protein ARP1 antibody; ARP1 antibody; Brx1 antibody; Homeobox protein PITX2; homeobox protein PITX2 antibody; IDG2 antibody; IGDS antibody; IGDS2 antibody; IHG2 antibody; IRID2 antibody; MGC111022 antibody; MGC20144 antibody; Otlx2 antibody; paired-like homeodomain 2; paired-like homeodomain 2 antibody; Paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor 2 antibody; pituitary homeo box 2 antibody; Pituitary homeobox 2; pituitary homeobox 2 antibody; PITX2 antibody; PTX2 antibody; RGS antibody; RIEG antibody; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; rieg bicoid-related homeobox transcription factor 1 antibody; RIEG1 antibody; RS antibody; Solurshin; solurshin antibody
Gene Aliases: ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PITX2; PTX2; RGS; RIEG; RIEG1; RS
UniProt ID: (Human) Q99697
Entrez Gene ID: (Human) 5308