Anti-PIWI-L2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the internal region of human PIWI-L2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cancer/testis antigen 80; CT80; Miwi like; Miwi likw; piwi like homolog 2; PIWI-L2; piwi-like 2; piwi-like homolog 2; Piwi-like protein 2; PIWIL2; piwil2-like protein; PL2L106; PL2L80A; testicular tissue protein Li 141; unnamed protein product

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Gene Aliases: CT80; HILI; Mili; PIWIL1L; PIWIL2

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UniProt ID: (Human) Q8TC59, (Mouse) Q8CDG1

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Entrez Gene ID: (Human) 55124, (Mouse) 57746

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Function(s)

nucleic acid binding RNA binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity protein binding hydrolase activity piRNA binding metal ion binding translation initiation factor

Process(es)

regulation of translation spermatogenesis cell differentiation germ-line stem cell population maintenance gene silencing by RNA piRNA metabolic process negative regulation of circadian rhythm oogenesis rhythmic process meiotic cell cycle positive regulation of meiosis I secondary piRNA processing piRNA-mediated gene silencing by mRNA destabilization transposable element silencing by heterochromatin formation transposable element silencing by piRNA-mediated heterochromatin formation transposable element silencing by mRNA destabilization transposable element silencing by piRNA-mediated DNA methylation positive regulation of cytoplasmic translation pachytene RNA 5'-end processing multicellular organism development DNA methylation involved in gamete generation positive regulation of translation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PIWI-L2 Polyclonal Antibody

Product Details

600-401-DP4

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

References (0)

Bioinformatics

Performance Guarantee

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