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Invitrogen
PIWIL2 Polyclonal Antibody
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FIGURE: 1 / 2
PIWIL2 Antibody (PA5-23438) in IHC (P)
Immunohistochemistry analysis of PIWIL2 in formalin-fixed, paraffin-embedded mouse testis tissue. Samples were incubated with PIWIL2 polyclonal antibody (Product # PA5-23438) using a dilution of 5 µg/mL. Isotype control (top left) and this antibody (bottom left, right).
Product Details
PA5-23438
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 30 to 80 of mouse Mili.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 100% homologous in rat, 87% homologous in human and dog, and 81% homologous in opossum.
Target Information
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Miwi like; Miwi likw; piwi like homolog 2; PIWI-L2; piwi-like homolog 2; Piwi-like protein 2
Gene Aliases: Mili; Piwil1l; Piwil2
UniProt ID: (Mouse) Q8CDG1
Entrez Gene ID: (Mouse) 57746
pachytene
RNA 5'-end processing
regulation of translation
multicellular organism development
spermatogenesis
cell differentiation
germ-line stem cell population maintenance
gene silencing by RNA
piRNA metabolic process
DNA methylation involved in gamete generation
positive regulation of translation
oogenesis
meiotic cell cycle
positive regulation of meiosis I
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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